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Identification of New Lactone Derivatives Isolated from Trichoderma sp., An Endophytic Fungus of Brotowali (Tinaspora crispa)

Scientific Journals of Bogor Agricultural University

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Title Identification of New Lactone Derivatives Isolated from Trichoderma sp., An Endophytic Fungus of Brotowali (Tinaspora crispa)
 
Creator ELFITA, .; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University,
Jalan Raya Palembang Prabumulih Km 34, Indralaya, Kabupaten Ogan Ilir 30662, Indonesia
MUNAWAR, .; Department of Biology, Faculty of Mathematics and Natural Sciences, Sriwijaya University,
Jalan Raya Palembang Prabumulih Km 34, Indralaya, Kabupaten Ogan Ilir 30662, Indonesia
MUHARNI, .; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University,
Jalan Raya Palembang Prabumulih Km 34, Indralaya, Kabupaten Ogan Ilir 30662, Indonesia
SUDRAJAT, MASTUR ADHY; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University,
Jalan Raya Palembang Prabumulih Km 34, Indralaya, Kabupaten Ogan Ilir 30662, Indonesia
 
Subject endophytic fungus; Trichoderma sp.; Tinaspora crispa; lactones
 
Description Endophytic fungi is a rich source of novel organic compounds with interesting biological activities and a high level of structural diversity. As a part of our systematic search for new bioactive lead structures and specific profiles from endophytic fungi, an endophytic fungus was isolated from roots of brotowali (Tinaspora crispa), an important medicinal plant. Colonial morphological trait and microscopic observation revealed that the endophytic fungus was Trichoderma sp. The pure fungal strain was cultivated on 7 L Potatos Dextose Broth (PDB) medium under room temperature  (no shaking) for 8 weeks. The ethyl acetate were added to cultur medium and left overnight to stop cell growth. The culture filtrates were collected and extracted with EtOAc and then taken to evaporation. Two new lactone derivatives, 5-hydroxy-4-hydroxymethyl-2H-pyran-2-one (1) and (5-hydroxy-2-oxo-2H pyran-4-yl) methyl acetate (2) were obtained from the EtOAc extracts of Trichoderma sp. Their structures were determined on the basic of spectroscopic methods including UV, IR, 1H-NMR, 13C-NMR,  HMQC, and HMBC.
 
Publisher Bogor Agricultural University, Indonesia
 
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Date 2014-03-26
 
Type info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article
 
Format application/pdf
 
Identifier http://journal.ipb.ac.id/index.php/hayati/article/view/7726
 
Source HAYATI Journal of Biosciences; Vol 21, No 1 (2014): March 2014; 15-20
2086-4094
1978-3019
 
Language eng
 
Relation http://journal.ipb.ac.id/index.php/hayati/article/view/7726/pdf